Transcriptomics profiling of human SGBS adipogenesis
نویسندگان
چکیده
منابع مشابه
Transcriptomics profiling of human SGBS adipogenesis
Obesity is an ever-growing epidemic where tissue homeostasis is influenced by the differentiation of adipocytes that function in lipid metabolism, endocrine and inflammatory processes. While this differentiation process has been well-characterized in mice, limited data is available from human cells. Applying microarray expression profiling in the human SGBS pre-adipocyte cell line, we identifie...
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BACKGROUND HIV-1 Tat protein has been shown to play multiple roles in the pathogenesis of AIDS; however, there is no information currently available on its effects on adipose tissue alterations. We have studied the effects of Tat on SGBS adipocytes to gain insight on its role on the development of lipodystrophy. METHODS SGBS preadipocytes were exposed to Tat during and after differentiation. ...
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Transcription factors (TFs) represent key factors to establish a cellular phenotype. It is known that several TFs could play a role in disease, yet less is known so far how their targets overlap. We focused here on identifying the most highly induced TFs and their putative targets during human adipogenesis. Applying chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq) in the hu...
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ژورنال
عنوان ژورنال: Genomics Data
سال: 2014
ISSN: 2213-5960
DOI: 10.1016/j.gdata.2014.07.004